Endocrine Abstracts

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been associated with several human metabolic disorders and is converted from inactive 11-keto form to glucocorticoid (GC or cortisol). GC overproduction or hypercortisolism is a major diagnostic factor of Cushing syndrome and Anorexia. GCs regulate carbohydrate, fat, and protein metabolism.Materials and methods: Previously we established porcine fibroblasts overexpressing 11&#...

Glucocorticoid, known as cortisol, is a steroid hormone essential to the maintenance of homeostasis, and is released in response to stress and low blood glucose concentration. It is converted from cortisone by 11β hydroxysteroid dehydrogenase type 1 (11β HSD1). The liver plays a major organ in metabolism, has numerous functions, mostly consists of hepatocytes, and is a principal target of cortisol. In murine model, it was observed that too much cortisol or overexpres...

Sex steroid hormones effect on the early embryo-development and regulate the calcium signaling in cardiac muscle. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the effect of P4 on early differentiation of mouse embryonic stem (mES) cells into cardiomyocytes, the hanging-drop method was performed to form embryoid bodies (EB). The mouse EBs (mEB) were suspended, attached onto six well plates and cultu...